Problem/Objective: The objective of this study is to identify tobacco-related disparities (TRD) among Los Angeles County (LAC) residents to guide the planning of countywide smoking cessation efforts. Methods: Analyses are based on data from population-based random-digit-dial telephone health surveys conducted among LAC adult residents in 2003 (n=8,167) and 2005 (n=8,648). Two-way and stratified analyses, followed by logistic regression to assess complex models, were used to identify TRDs. Dependent variables included current smoking status and provider advice to quit smoking; independent variables included race/ethnicity, gender, education, Federal Poverty Level (FPL), and acculturation level. Results: Highlights of the statistically significant findings include the following: among females, higher smoking prevalence was found for African Americans (22.9%) than for Whites (14.1%), Asians (8.0%), or Latinas (7.3%); among males, higher smoking prevalence was found for African Americans (26.9%) than for Whites (16.9%) or Latinos (16.6%); fewer Latinos (29.5%) were advised to quit smoking by healthcare providers than were African Americans (49.8%), Asians (59.1%), or Whites (47.8%); among Mexican-born immigrants with less than a high school education, increased smoking was observed among those with higher versus lower acculturation (females—18.9% vs. 4.5%; males—41.0% vs. 18.3%); and among African American females, smoking prevalence was inversely related to FPL (40.4% for less than 100% FPL, 24.7% for 100% to 200% FPL, and 10.2% for greater than 200% FPL. Conclusions: African Americans and Latinos are disproportionately affected by TRDs and in particular need of smoking cessation services. Planning of these services should be guided by the specific socio-demographic characteristics of the targeted populations.