Methods: Retrospective review of clinical data was collected during tobacco (face-to-face and phone) treatment. Proxy measures were collected representing biopsychosocial aspects of tobacco addiction theorized to encourage/discourage successful cessation. Biological factors were defined as physiological addiction including gender, time used, Fagerstrom score, previous addiction or psychiatric counseling. Social indicators defined as ethnicity, education, employment, age, immediate family/or acquaintance support and included indicators of financial hardship e.g. income and insurance (for counseling and/or medications). Psychological addiction was defined as usage as mood enhancer, perceived quit needs including a physical life changing factor (LCF) e.g. chronic disease, or routine use and age of regular use. Indicators differences between non-use/use were compared sample-wide and program stay using chi-square/ t-test to identify logistic regression modeling confounders. Results: 746 enrollees between January 2002 and November 2006 (mean years use 29.65±12.3), those >3 mos. were 1.46 times more likely to be abstinent within past 7-days than <3 mos.(95% CI: 1.03, 2.05: p=0.031). Those <3mos. were more likely to use tobacco to enhance mood (64% vs 54.5%) and part of a routine (61.6% vs 53%) than >3mos. (p=0.017 and p=0.035). >3 mos. were older (51.39±12.66) than <3mos. (48.42±12.58) p=0.005. Conclusions: Family support, employment were significant facilitators >3mos. not for <3 mos. Previous psychiatric counseling was deterrent to successful cessation at >3mos. Tobacco usage and physical LCFs are indicators of abstinence < and >3mos.