Problem/Objective: The Centers for Disease Control and Prevention's Office on Smoking and Health (OSH) is helping state tobacco control programs and other partners to build their capacity to conduct culturally sensitive surveillance and evaluation to reduce tobacco-related disparities among specific Hispanic/Latino population subgroups. The purpose of this presentation is for participants to learn about a modified Adult Tobacco Survey that is culturally appropriate for Hispanic/Latino populations and to describe opportunities for collaboration with partners who have an interest in reducing tobacco-related health inequalities among Hispanic/Latino population subgroups. Methods: The most current surveillance and evaluation data on Hispanic/Latino subgroups will be presented during the presentation. Results: Participants will gain knowledge on tobacco related disparities among Hispanic/Latino subgroups. Recent use of the survey via face-to-face interviews with Hispanics residing in Colonias in El Paso, Texas will be discussed. Participants will also understand lessons learned and recommendations of the development of appropriate survey instruments as well as survey challenges of reaching Hispanic/Latino population subgroups, including recent Hispanic immigrants. Furthermore, participants will understand the importance of collaboration primarily with partners who have vested interests in populations at risk for tobacco-related disparities. Conclusions: Participants will learn about tobacco-related disparities among Hispanic/Latino population subgroups, methods used to tailor a national survey to be more culturally appropriate for Hispanic/Latino subgroups (e.g., Puerto Ricans, Cubans, Mexicans, Central and South Americans), and strategies used to create partnerships that work toward identifying and eliminating tobacco related disparities among Hispanic/Latino populations.